Charlotte, an older woman who has spent the last six months taking care of her husband Eddie, is rushed to Princeton Plainsboro for immediate treatment after collapsing from respiratory failure at Eddie's deathbed. With both in the hospital, the husband and wife team becomes a double mystery when Eddie's condition sporadically improves while Charlotte's condition deteriorates. 

Dr. Lawrence Kutner dies of suicide using a gun without any explanation why. While most of the cast grieve, House tries in vain to understand why Kutner died. 

The team takes on the case of a deaf 14-year-old named Seth who collapsed after he started "hearing" explosions while competing in a wrestling match. Meanwhile, House's lack of sleep starts to play tricks on his mind, but he finds his insomnia may be a gift instead of a burden.