Tension reaches new heights when Cuddy faces sobering news that forces her to reevaluate her priorities. While House is distracted by his concern for Cuddy's well-being, the team treats a teenage patient whose worsening symptoms and suspicious body scars indicate more than just physical illness. Sensing the teen's troubled emotional and mental state, Taub turns to the patient's personal life for clues and uncovers disturbing home videos that could put the lives of his peers in danger. Meanwhile, Cuddy remains hopeful that House will be fully present when she needs him most, and a series of dreams, including a musical scene choreographed by Mia Michaels, provide glimpses into her life and her relationship with House.

A young homeless man who is a former drug addict is found in a park showing signs of olfactory impairment and horrific scars and burn marks on his chest. With an uncertain identity and the patient's severely worsening conditions, the team looks to the patient's records and family history to understand his detachment. Meanwhile, Cuddy reveals her guilt to Wilson about breaking up with House.