When a waitress with a perfect memory suffers temporary paralysis, her older sister visits her in the hospital, which triggers high stress levels and even more health complications. Meanwhile, Foreman volunteers to help Taub prepare for a medical examination, and House, determined to help Wilson get back in the dating scene, discovers Wilson's secret new companion.

After breaking out in a severe rash triggered by caustic chemical exposure at his blue-collar job, a patient is admitted. As the team treats him, they discover that he has led his wife to believe he is still maintaining his once-lucrative real estate career. Meanwhile, Cuddy is honored with an award and needs House to be at the charity event for support. But his attendance is threatened when his patient's battle to survive forces him to question his practice and happiness. Chase and Masters teach each other a lesson in forging meaningful personal and professional relationships.