Over his years performing autopsies at Princeton-Plainsboro Teaching Hospital, Dr. Peter Treiber often identifies mistakes made by physicians that caused the patient's death. These observations make him question the skills of nearly all the doctors on staff, all that is, except House. When he falls ill, he demands that only House make medical decisions concerning his care. Unfortunately, House and Wilson have taken off on an impromptu road trip without telling anyone, leaving the team to figure out how to treat Treiber while making him believe that House is calling all the shots. Lastly, Chase decides to step out of House's shadow and leave the hospital.

The one-hour retrospective special looks at this groundbreaking seminal series, including the finale, interviews with the series stars and producers, unique original content, and other surprises. It aired just before the series finale Everybody Dies.