House and Park treat a patient, Benjamin Byrd, who collapsed suddenly after making a surprisingly large charity donation. When the patient offers to donate an organ to another patient, the doctors must convince Dr. Adams to help them confirm whether Benjamin is in his right mind or not. They are convinced his extreme altruistic behavior is a symptom of a deeper medical disorder. Feelings of guilt hamper thirteen's pursuit of happiness.

A man well-respected in his community suddenly collapses, and in diagnosing his symptoms, the team discovers that the patient has been hiding dark and dishonest secrets about his personal and professional life. But when the patient openly confesses his wrongdoings to his family and community, he compromises his chances of receiving the proper medical treatment. Meanwhile, Chase and Taub rejoin the team, and Taub struggles to balance work and fatherhood. House will stop at nothing to manipulate Taub into taking a DNA test to prove he is the father of his two six-month-old daughters.