An Alzheimer's patient visits Princeton Plainsboro as part of a hospital-sanctioned drug trial. When he inexplicably suffers violent blood vomiting and an increasingly explosive temper, the team unravels a deeper marriage conflict between the patient and his dutiful wife. Meanwhile, when Wilson tells House about a patient who has never had sex with her husband of 10 years, claiming A-sexuality, House makes a wager that there has to be an underlying cause. Also, House and Foreman butt heads.

When a violent incident involving a patient has serious consequences for one staff member, House and the team are placed under review by Dr. Walter Cofield, Foreman's former mentor and current Chief of Neurology. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team's unconventional brand of collaboration against their ability to save lives.