In the remote heights of the Transylvania Alps, Dracula awakes after a 100-year sleep. Dracula starts havoc by releasing a strange glowing powder that turns people into vampires. Meanwhile, Batman and Robin receive a distress call and speed off to Transylvania. They search Dracula's castle, only to get captured by Dracula himself. Later Wonder Woman and Aquaman arrive in Transylvania after the Wonder Twins report it was taken over by bats, only to be attacked by dozens of mindless vampires. Another report of vampire attacks was made and this time Superman went to Vienna to stop them. While in Vienna, Superman runs into Dracula, who was continuing his plans of conquest, and gets turned into a vampire. Realizing Superman is under Dracula's control, the Wonder Twins attempt to stop the victimized Man of Steel. Wonder Woman, Aquaman, Batman, and Robin all escape the face of danger, only to find that Superman and the Wonder Twins have been turned into vampires and are turning nearly everyone else into vampires as well. The four Super Friends regroup at the Biological Research Center in Switzerland to find a way to reverse the effects the vampires have on people. They now must find a strange breed of South American bat in the Andes Mountains whose cave has gases that could reverse the vampire effect. It is now up to the Super Friends to transform the vampires back to normal and figure out a way to stop Dracula.

After an experimental satellite from Kennedy Space Center falls back to Earth it breaks, releasing deadly radioactive energy. The Super Friends then receive a distress call from the West Coast saying Death Valley is being overrun by giant desert beasts. Wonder Woman and the Wonder Twins stay behind to check the Justice League computer for more information, while the rest of the Super Friends head to Death Valley. At Death Valley they find wreckage and a man who says giant lizards had nearly destroyed the town. As Superman continues to search for the mysterious giant beasts, he stumbles upon some mutated giant earthworms that he must save some teens from. As Aquaman, Batman, and Robin fight the creatures that attacked them, Wonder Woman finds out what happened via the Justice League computer and heads to NASA for more information. As Wonder Woman approaches the location of the downed satellite, the radiation turns her into a giant beast. As the Wonder Twins try to stop Wonder Woman's destruction of a military base, the radiation genetically alters them into giant beasts. Meanwhile, giant earthworms are digging holes into California's coast, which will potentially sink. To save everyone, the Super Friends must stop the creatures and turn them and the "Wonder" heroes back to normal.