Detective Sherlock Holmes, along with his sober companion, Dr. Joan Watson, uses his uncanny ability to read people and analyze crimes to assist the NYPD on some of their more difficult cases. In the season premiere, Holmes consults on a home invasion that resulted in murder.

Sherlock and Watson consult on a child abduction case involving a serial killer who is nicknamed "The Balloon Man," because he leaves a signature batch of balloons at each of his crime scenes.