When two New York City paramedics are killed during a kidnapping, Holmes and Watson join the manhunt to find the murderer and the woman he abducted. Also, Holmes learns important information about his recovery sponsor, Alfredo, that strains their relationship.

Holmes and Watson look into the death of a member of Holmes' online beekeeping community who was a researcher looking into a deadly Northeast honey bee outbreak. During the investigation, they meet Tara Parker, a brilliant entomologist, academic and the leader of New York's beekeeping society. Also, Captain Gregson enlists Watson's services in an off-book investigation that helps him make a life-changing decision.