When a survivalist doctor goes missing, Holmes and Watson must determine whether he's purposely gone off the grid or if he's a victim of foul play. Also, Holmes exhibits odd behavior when his romantic relationship with Fiona hits a critical point.

As Holmes and Watson investigate a woman's murder, they discover her death is linked to a piece of artwork that has ties to a crime that was committed when she was in college. Also, in the wake of a shocking personal revelation, Watson attempts to forge a connection with a recent client.