When Watson is implicated in a DEA investigation into doctors writing illegal prescriptions, she and Holmes search for the person using her medical license to sell drugs.

When Holmes and Watson investigate a clown's murder upstate, they discover a connection between his death and the creation of a new weaponized virus. Also, Watson helps Bell when he's targeted by his new love interest Chantal's ex-husband in attempt to sabotage her career at the district attorney's office.