As the second volume of Heroes begins, the fates of Peter, Nathan and Matt are revealed, following the horrible showdown with Sylar and Peter's uncontrolled nuclear detonation miles above New York City. As everyone attempts to move on, a new sinister force begins stalking and murdering Heroes. With the family hiding in Southern California, H.R.G. and Claire attempt to live as inconspicuously as possible; which proves to be easier said than done. Meanwhile, after landing in feudal Japan, Hiro meets his hero Takezo Kensei. Twins Maya and Alejandro Herrera hope to make the crossing into the U.S. from Mexico, in hopes of finding help with their deadly abilities.

Upon his return to New York, Suresh is unnerved to find an undiscovered Issac Mendez painting that foretells death of someone close to him. Both Claire and H.R.G. pursue their own secret personal agendas. Determined to make it to the U.S., Maya uses her deadly abilities to free Alejandro from a Mexican jail. Ando returns to his job in Japan and makes a happy discovery. Meanwhile, in Japan's past, just when Hiro had written off Kensei, his childhood hero surprises him. Niki and Micah leave Las Vegas in an attempt to start over. Later, Niki and a lost Hero individually strike shady bargains to reach their goals. Two familiar people with abilities make an unexpected return.