In the aftermath of the showdown against Arthur Petrelli, the Petrelli brothers find themselves battling against one another and Nathan makes a move that will have global repercussions. Meanwhile, Sylar holds Claire, H.R.G., Meredith and Angela hostage at Primatech and a face-off ensues. Elsewhere, Ando, Matt and Daphne continue their attempts rescue Hiro -- and Dr. Suresh may be their only hope.

Following a chain of unexpected events, our Heroes are on the run from their latest adversary and one of their own, Nathan Petrelli. After Matt paints a series of prophetic images, the tragic fate of someone close to him is revealed. Elsewhere, Sylar continues his search for his father and encounters a young outcast with information and an ability of his own.