Following a chain of unexpected events, our Heroes are on the run from their latest adversary and one of their own, Nathan Petrelli. After Matt paints a series of prophetic images, the tragic fate of someone close to him is revealed. Elsewhere, Sylar continues his search for his father and encounters a young outcast with information and an ability of his own.

While being held hostage, HRG is subjected to Matt Parkman's unique brand of interrogation, revealing how he became involved with Nathan's government plot to capture those with abilities. Meanwhile, Matt's discoveries bring Peter face-to-face with "The Hunter".