In the premiere of this comedy about twentysomething women navigating their way through life in New York, Hannah swings and misses at two curves when her parents rescind their financial support and she loses her unpaid internship. Meanwhile, Hannah's roommate, Marnie, throws a dinner party for their nomadic friend Jessa, who's returned from yet another journey.

Hannah contacts her college boyfriend to find out how she contracted an STD, but learns perhaps even more shocking news from him. Meanwhile, Marnie is smitten with a pretentious artist at a gallery opening; and Jessa lands a babysitting job.