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Jackie, Dr. Prince and Akalitus are forced to run the ER without nurses when Zoey leads a walkout to protest the hospital closing. Meanwhile, Jackie battles her cravings when she treats a heroin addict.
Jackie stirs up trouble when she rallies her co-workers against the developers, but an attractive offer challenges her allegiance. Meanwhile, Coop prepares for his last day at All Saints, and his replacement arrives and surprises everyone with his carpe diem attitude.
Jackie becomes determined to stop dealing and makes one last purge of her stash with Eddie, but the deal goes awry just as their relationship reaches a new level. Meanwhile, Zoey blames herself for a patient's death and Carrie steps forward as an unlikely ally; and Dr. Prince and Akalitus bond over lunch when she reveals something from her past.