The Gallaghers adjust to life during the pandemic: Frank fears the loss of the South Side to gentrification, while bar closures force Kev and V to get creative at the Alibi. Sleep-deprived Lip and Tami work to make their new house a home as Carl finishes his time at the police academy. Debbie becomes her own boss and deals with the repercussions of her statutory rape conviction of 17-year-old Julia. Ian and Mickey's honeymoon phase is over as they have very different ideas about what married life would be.

In a rush to get out of the house, Debbie loses track of Franny and has to balance her search for Franny with her handy-woman jobs. Meanwhile, Frank and Franny have a day of weed runs and adventure. Ian and Mickey question who is the "man" in their relationship. A delighted Carl gets a new Training Officer who loves to kick ass. When Brad and Cami learn about their newborn baby's health complications, Lip and Tami step in to help. Kev's newfound money and lack of modesty prove to be trouble.