Ian returns home from the psych ward but refuses to accept his bipolar diagnosis or take his medication; Gus tells Fiona he is going on tour and that they need time apart; Frank recovers from his gunshot wound and plots revenge against Sammi; Carl is asked by his boss to run drugs to Indiana; Lip convinces Kev to sell drugs in the dorms.

Frank starts to enjoy the company of his new sick friend and formerly uptight doctor, but she dumps him when she suspects he is developing feelings for her.