Dr. Helen Magnus, her daughter Ashley, and new to the Sanctuary, Dr. Will Zimmerman release three women from a mysterious crypt in Scotland, bringing them back to the Sanctuary for refuge. Unbeknownst to the team, and the women themselves, they have extraordinary powers. And their disappearance does not go undetected by a powerful cabal, resolute on reclaiming what it determines is theirs.

Returning with an abnormal captured in the Himalayas, Magnus and Will are stranded from civilization and aid after their plane goes down in a desolate mountain range. While anxiously waiting for a rescue team, the surviving passengers begin to fall victim to vicious and deadly attacks throughout the night. It becomes chillingly apparent that surviving the cold is the least of their worries and no one, not even Magnus and Will, is above suspicion.