Vincent is captured on a convenience store surveillance video while preventing a robbery, and Cat warns him to be extra careful when his photo appears in the newspaper. Cat and Tess investigate the disappearance of a woman named Amy, who has gone missing after her fiancé, Dr. Michael Walters, surprised his bride-to-be by placing their engagement announcement in the paper that morning. Evan runs Amy's fingerprints and discovers her true identity, while Cat wonders if her disappearance was intentional after Vincent mentions that he and JT have an escape plan to clear out of their loft without a trace in a matter of minutes. Later, Michael also goes missing and Joe learns that his team has been deceived. Meanwhile, Heather is planning a surprise birthday party for her sister, forcing Cat to postpone her birthday plans with Vincent. At the party, Cat and Evan share a surprising moment.

Thinks Vincent may somehow be involved in Cat's homicide investigation after she mentions a local college fraternity brother was brutally killed. JT examines Vincent to determine the cause of his increasingly frequent blackouts, but when Vincent starts to beast out, JT is forced to tranquilize him. Meanwhile, Evan and his new intern find a strange cut on the victim's ankle, which matches that of a female cadaver left on campus a year earlier. As Evan works to uncover more clues from the crime scene, he is kidnapped. Cat begs Vincent to help find Evan and save his life, yet she doesn't realize that she's putting Vincent's life in serious danger.