When multiple earthquakes strike simultaneously across the globe in both universes, the Fringe teams on both sides unite in their quest to defeat a common foe. As time counts down, the fate of both universes hangs in the balance.

Pushed to breaking point, Fringe Division desperately attempts to prevent a catastrophic event orchestrated by David Robert Jones and his hidden associate, Dr. William Bell. Meanwhile, the Observer known as September arrives with a dire warning that will alter the course of humanity's future.