In the series debut, housewife Nancy Botwin struggles to deal with the sudden death of her husband, while her best friend and neighbor Celia Hodes learns a devastating secret when she tries to catch her daughter in the act with Nancy's son.

A mountain lion is on the prowl in Agrestic, but it's the medical marijuana facility that is causing the most havoc in Nancy's life. Faced with the dilemma of having to compete, Nancy has to get cooking. Silas makes a move on Megan causing him some colourful problems of his own and Celia and Isabel's war over weight issues gets dirty.