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With tensions between them at an all-time high, Harley heads to Bensonhurst for a family emergency, while Ivy vows to take down Lena once and for all.
The team gains a surprising new addition in the wake of a devastating loss. Meanwhile, as Ivy and Harley set out to bring the murderer to justice, Bane must protect Goldie and the other school kids from citywide destruction.
Harley and Ivy attempt to mend the longstanding childhood rivalry between the Luthor siblings before Metropolis is destroyed. Meanwhile, an unlikely alliance forms between Bruce, the Joker and Lois as they fight for their lives amid the chaos in the city.
The fifth season of Harley Quinn finds Harley (Kaley Cuoco) and Ivy (Lake Bell) in a new location: Metropolis! – the home of all things Superman, Lois Lane, and the Daily Planet. Harley and Ivy discover that something sinister is at play and all is not what it seems. Looming threats include Lex Luthor and his sister, Lena Luthor, plus fan-favorite Brainiac. But of course, Harley's crew of misfits and allies will join her on this irreverent journey that takes no prisoners in having fun in the DC sandbox.