Chuck battles with his cover love life and real love life when he meets a very pretty girl named Lou, who seems interested in the real Chuck. On the other hand, his relationship with Sarah heats up as they go on a double date with Ellie and Captain Awesome and try to explain their sex life. Meanwhile, a poison specialist is trying to obtain codes to nuclear facilities and is using a "truth" poison to help get his answers. After all are exposed to the truth, Chuck soon discovers a lot about his partners.

It's Thanksgiving and Chuck's nemesis, Bryce Larkin, returns to his life after being ruled dead earlier in Chuck's life. Secret internal committees trying to destroy the intersect, now better known as Chuck's brain, saved Bryce in hopes he would be able to help them locate it. Bryce needs Chuck to help prove to Sarah, Casey and the rest of the CIA that he is not rogue. Upon seeing Bryce and Sarah back together, former lovers and partners, Chuck grows jealous and doubts any future with Sarah. Meanwhile, Buy More is prepping for the biggest shopping day of the year and Morgan is left in charge to ensure all runs well.