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Chuck feels like his life is falling apart when he can't flash and gets left behind for a mission. While Shaw, Sarah and Casey go on without him, Chuck finds himself in a sticky situation back at the base.
Chuck promises to cook dinner for Hannah, Ellie and Awesome but must first assume the identity of the world's most dangerous assassin for his latest mission. Meanwhile, Sarah is determined to keep her relationship with Shaw strictly professional.
Casey carries out a side mission for his old commanding officer James Keller that leads to him committing treason. When Chuck learns the dark truth about Col. Keller, he and Sarah set out to break Casey out of jail and clear his name. Meanwhile, Awesome's plan to keep Ellie out of danger gets more difficult when she gets her dream fellowship.
After downloading the Intersect 2.0, Chuck finally chooses to be a spy, to Sarah's chagrin. Six months later after failing spy school, he is fired from the CIA and also lost the love of his life. CIA Agent Daniel Shaw takes over Team Bartowski to aid Chuck's journey into becoming a spy.