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Hank deals with some lingering aftereffects from his confrontation with Tuco; bills are piling up at the White house and tensions are beginning to run high; Jesse organizes a crew of dealers to take their product to the streets.
Despite Walt's attempt to reconnect with the family, a suspicious Skyler keeps him at arm's length and worries about what he's been up to while he's been away from the house; Jesse finds himself on the streets once again and struggles to improve his lot in life.
Walt returns to teaching at the high school; when Skinny Pete gets taken advantage of and ripped off, Jesse steps in, but bites off more than he can chew; Skyler takes the opportunity to show her appreciation for Gretchen's kindness in picking up the tab for Walt's treatments.
As their partnership reaches new heights, Walt and Jesse begin to see the extremes of the drug trafficking business. Their trademark blue meth is making them rich, but it's getting more difficult than ever for Walt to conceal the truth from his wife Skyler, his son Walter Jr., and his DEA agent brother-in-law Hank. Walt struggles to maintain control of his life as he contends with vicious drug dealers, an increasingly distant wife and son, the impending birth of his daughter, and a strung-out business partner – all while battling terminal lung cancer.