In the third-season premiere, Walt faces a new threat on a new front and deals with an increasingly angry Skyler, who must consider what to do next with her life and the kids'. Meanwhile, Jesse comes face-to-face with some startling self-revelations.

Walt disregards Skyler's demands and the rift between them widens dramatically, pushing her to take even more drastic steps. Meanwhile, continuing anxiety and panic attacks plague Hank, which leads to a serious situation at the Drug Enforcement Agency.