Walt disregards Skyler's demands and the rift between them widens dramatically, pushing her to take even more drastic steps. Meanwhile, continuing anxiety and panic attacks plague Hank, which leads to a serious situation at the Drug Enforcement Agency.

When Gus intensifies efforts to persuade Walt to get back in the meth business, Jesse takes exception and a rift appears in his and Walt's personal relationship. Meanwhile, Skyler's new relationship isn't turning out as she'd like; and Marie tells Skyler about her concerns for the increasingly troubled Hank and his well-being.