The FBI's search for elusive serial killer Francis Dolarhyde intensifies as Will Graham begins envisioning himself in Dolarhyde's tormented psyche. Wading deeper into dangerous territory, Will enlists the help of Hannibal Lecter to assist with the killer's profile. Meanwhile, Alana Bloom reminds Will that the last time that he and Hannibal worked together things didn't end well, but Will sees no other option. Elsewhere, a new woman (guest star Rutina Wesley) comes into Dolarhyde's life.

Will Graham and Jack Crawford are certain that Francis Dolarhyde will strike again with the approaching full moon, but without a solid lead, they remain unable to predict the next family on the Red Dragon's hit list. Certain that Hannibal Lecter can lead the FBI to Dolarhyde, Alana Bloom offers Hannibal a chance at redemption. Meanwhile, Dolarhyde struggles with his feelings about the one good thing that remains in his life-his coworker Reba.