Sensing their time in Florence is coming to an end, Bedelia Du Maurier and Hannibal consider their parting as Hannibal plans for his final stand. Meanwhile, Will Graham and Jack Crawford reunite, but Jack remains uncertain about Will's true loyalty. Back in the States, Mason Verger hungrily makes plans for Hannibal's capture, while Alana Bloom and Margot Verger makes plans of their own for Mason.

Dr. Hannibal Lecter has been under lock and key for three years at the Baltimore State Hospital for the Criminally Insane, when a new villain arises in Francis Dolarhyde, also known as "The Tooth Fairy." As the investigation unfolds Jack Crawford approaches Will Graham to help catch this vicious serial killer who is targeting families.