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Rick and Jerry's minds are accidentally scrambled; they have to learn to set aside their differences to save their family.
When Mr. Poopybutthole overstays his welcome at the Smith household, the rest of the family get Rick to deal with the problem. However what starts out as a hang out of friends quickly turns into an out of control bar crawl, especially when a special guest joins the group.
Rick, along with the president and Dr. Wong, deal with a situation when an ex-lover of Rick takes over Virginia.