In the opening episode paramedic Neil Weaver and technician Steve Gennoe are called to help 36-year-old Andy who's been attacked by a gang. Firearms officers are already on the scene. Andy was stabbed in the head and back. As Andy's condition deteriorates it's a race against time to get him to hospital.

Meanwhile paramedic Joe Wilson and technician Sam Grosvenor race to 24-year-old Brogan who's gone into anaphylactic shock at a restaurant. He has an allergy so severe that he's reacted to nuts in someone else's meal. Every second counts as Brogan's airway swells up and he struggles to breathe. If he's not treated he could die.

Finally 10-year-old Tyreece has gone over the handlebars of his bike and was knocked unconscious. He can't move and may have broken some bones. Paramedic Matt Rodwell and student paramedic Aaron Campbell are worried he could have sustained a serious head injury as Tyreece can barely speak and can't remember his birthday.