It's Midnight Run, Alphas-style as Hicks and Kat transport a valuable Parish asset: a babbling, off-his-nuts memory sponge Alpha named Mitchell. Mitchell just might hold the strategic intel they need to stop Parish... if they can outrun and outwit Roland's seemingly indestructible Alpha "caretaker". Meanwhile, Rosen is on his own hunt for Parish' Achilles' heel, a weak point to strike at. But Senator's Burton sudden presence in the Alphas office threatens to expose Rosen and Nina's own Achilles' heel.

Separated from the team and haunted by vivid hallucinations of his daughter, Dani, an injured and increasingly desperate Doctor Rosen seeks a final confrontation with Alpha leader Stanton Parish. Meanwhile the team battles both the clock and their own mutual distrust to thwart Parish's deadly plans.