After successfully freeing the Detroit Lions from "The Curse of Bobby Layne", Peyton Manning gets ambushed by former Buffalo Bills wide receiver Steve Tasker and The Bills Mafia, who demand Peyton lift "The Buffalo Sports Curse". After hearing their pleas, Peyton meets up with Bills quarterback Josh Allen as they attempt to lift the curse.

Peyton Manning heads west to Malibu, CA, to meet up with Chargers head coach Jim Harbaugh to help him spend a day in his favorite TV show, The Rockford Files, climaxing in a wild ride along the California coast that would make Jim Rockford proud.