Paranoia strikes Monroe deeply as Neville disappears and Neville's son Jason makes a big decision. Meanwhile, the familial bond between Miles and Charlie grows stronger. Elsewhere, Miles experiences romantic attraction with both Rachel and Nora. And Rachel sets off on her dangerous quest to infiltrate the Tower and restore power to the world before Monroe can ignite a nuclear device.

Miles and Tom Neville find themselves fighting for the same cause but Miles still doesn't trust him. And Charlie, Jason and Nora attempt to pull off a daring river rescue of Dr. Stephen Camp to keep deadly anthrax out of the hands of Monroe. Meanwhile Rachel and Aaron are captured and threatened by Militia forces.