Miles and Tom Neville find themselves fighting for the same cause but Miles still doesn't trust him. And Charlie, Jason and Nora attempt to pull off a daring river rescue of Dr. Stephen Camp to keep deadly anthrax out of the hands of Monroe. Meanwhile Rachel and Aaron are captured and threatened by Militia forces.

Captive Nora is tortured and left for dead. Monroe learns of Rachael's attempt to reach the Tower but is unaware of her deadly plan for him. Meanwhile, Miles is desperate to find out how so many of his close associates are being brutally murdered. Later, Miles, Charlie, Neville, Jason, Hudson and Sanborn struggle to make it out of the Plains Nation to join Rachel and save her from what they believe to be certain death.