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Charlie challenges his group to do thirty-six hours of sleep deprivation therapy so that their "inhibitions come down and the truth comes out" - except the result turns out to be the exact opposite.
The new "evolved" Charlie has to deal with a ghost from his old carousing, baseball-playing days when a unattractive woman he slept with just to break a batting slump shows up as a new patient in group therapy.
A long-standing rivalry over who's a better therapist leads to war when Kate steals Patrick, one of Charlie's group patients.