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Frank has to go undercover for the FBI as an arms dealer to take on a radical group ready to unleash a deadly virus in the U.S. but a mole inside the FBI could expose him. Jules says this is his "first day" working for Frank.
Frank is offered the job of stealing a painting containing land deeds from a Russian-controlled home but finds himself in competition with another Transporter for the job. Frank meets Jules for the first time working for rival transporter Olivier Dassin.
Frank must help his sometime ally Inspector Tarconi when the man is set up by fellow cops during a raid on the home of a noted counterfeiter of medical groups. With Tarconi wanted himself, Frank must help him clear his name and stop the counterfeiter from a deadly shipment as well as rescue the captured Jules.