The 11 celebrity relatives vying to stake their own "claim to fame" and win the $100,000 prize are introduced. The first challenge is a talent show with a twist, determining who is at risk of the first elimination.

The fan-favorite challenge of Telephone returns, but added communication obstacles and an injury make it more challenging than ever. The recipient of the Wine Clue grows confident in a competitor's identity, and an alliance is tested at the Guess Off.