Bourdain travels to Mexico City, Oaxaca, and Cuernavaca to commune with local residents who express their passion through food, art, and the struggle for an improved quality of life. Bourdain talks with journalist Anabel Hernández on the impact of the area's drug trade-related violence and how it affects local quality of life.

Bourdain goes off the beaten path and explores some of the food and history of Mississippi including downtown Jackson's Big Apple Inn, known for its "Pig Ear Sandwich" and as a Civil Rights Era gathering place, and then travels into the Mississippi Delta to Po' Monkey's Social Club, a juke joint located in an old sharecropper structure.