TC's sister-in-law lands in the ER after falling down stairs, and complicated truths about the accident emerge. Meanwhile, staffers treat a boy who fell down a well; Ragosa's teen daughter visits the ER; and Drew spirals into a deeper depression.

Drew finds himself in the middle of a shooting at a friend's Army promotion ceremony and springs into action, disarming the shooter. Later, he has to treat his best friend's wife and finds that her bullet injury has revealed an even more severe medical condition. Topher and TC treat a young woman whose chronic bouts of psychosis are becoming a danger to herself and her family. The ER team has to scramble to diagnose and treat the young woman before she is arrested for her mysterious, violent behavior. Paul treats a nine-year-old boy with severe cystic fibrosis and his concern for the boy's health leads him to break a few rules regarding hospital protocol. Meanwhile, Ragosa is devastated when his financial troubles put his daughter's Quincea-era in jeopardy.