Jordan and Krista rescue the victim of a motorcycle crash on a deserted rural road. Miles away from an ER, they improvise emergency medical care for the injured motorcyclist and rush him to the nearest operating room -- in a veterinary hospital. Back at the hospital, TC and Paul race to diagnose the cause of a teenager's life-threatening overeating condition while Topher treats a friend who is concealing a dangerous secret. Meanwhile, Drew shrinks from the media's eye as his heroic gunman takedown goes viral, but he gets a welcome surprise when Rick returns.

Introduces the night shift team to his MMA group therapy leader Colonel Elwood "Smalls" Green, who surprises the group with special greeting from the White House. Jordan and Paul help a nine-year-old boy with a serious fever. When his high-strung mother begins to exhibit signs of distress as well, the team realizes there is more to the family dynamic than meets the eye. Topher is faced with a big decision about making an emergency trip overseas to help an old mentor. TC grapples with whether to accompany him on the journey. Meanwhile, Ragosa, Drew and Krista compete for the strangest cases of the night as the full moon brings out the worst in people.