In the first half of this two-part episode, the night shift crew is back for more action and the gang finds themselves immersed in a life-and-death rescue of a woman gravely injured in a car accident. While TC Callahan, Scott Clemmens and Topher Zia deal with the situation at the hospital, Drew Alister is serving time overseas in Afghanistan and he, along with colleague Syd Jennings, have to figure out a way around the cultural divide to treat a young Afghani woman. Jordan Alexander has recruited Shannon Rivera to the night shift team and the recent med school graduate is eager to prove herself, but her spunky, outspoken nature may not sit well with everyone, particularly Paul Cummings. TC's sister-in-law,

Drew returns from deployment in Afghanistan and can't seem to shake off the stress of being back from overseas. Things get crazy right away as he, Jordan and Kenny treat a bride (Lindsey Morgan, "The 100") and her wedding party who have been injured during the festivities, as well as her father, whose presence is not making things easier. Meanwhile, TC helps Topher entertain his demanding mother, whose extended visit is putting stress on the family.