TC and Paul pull out all the stops when a crane collapses on a worker at a busy construction site. As Paul works tirelessness to save the crush victim, an observer falls into a deadly gravel pit. TC throws himself into the pit and races to save the patient before he's swallowed by the shifting gravel. Back at the ER, Scott is shaken as the teenage boy he paralyzed returns to the hospital with new complications. Jordan lends support as the emotional case exposes complicated feelings from the past. Meanwhile when a life-saving donor matches with cystic fibrosis patient, Brianna, Drew determines the depth of his feelings for her.

In part one of this two-part season finale, Scott and Jordan face grave danger during a rescue mission at a rapidly spreading wildfire outside San Antonio. Tensions are high between Syd and TC as they find themselves in the middle of a humanitarian crisis on the Syria-Turkey border. Paul and Shannon argue over treatment for a patient. Meanwhile, a major setback threatens Drew's adoption plans for Brianna, Topher struggles to find a buyer for the hospital and medication goes missing.