Detectives search for answers after 34-year-old mother Annastasia "Annie" Hester is stabbed to death in a Portland, Oregon suburb; investigators uncover personal details that point to multiple suspects and possible motives.

Dateline (again) investigates the 2012 murder of Leslie Neulander, a 61-year-old woman who died in her 8,000 square-foot mansion in DeWitt, New York, a suburb of Syracuse. Neulander's death was initially reported as an accident, that she had a bout of vertigo, slipped and fell in the shower, fatally hitting her head on a marble bench in the shower.

In 2015, Leslie's husband, former OB/GYN Dr. Robert Neulander, was found guilty of her murder. After Neulander spent three years in prison, a court overturned the conviction in 2018 because of one juror's misconduct. Throughout his first and second trials, Robert Neulander has received strong support from his two children, Ari and Jenna, and Leslie's sister, Joanne London.