On the way to Sunyshore City, Ash and friends are walking through a grassland and come across Meowth of Team Rocket, who is injured. When they ask him what happened while treating his wounds, Meowth says that he was attacked by Team Galactic in a large building called the Fuego Ironworks. Not only that, Jessie, James, and even Looker of the International Police have been captured. Upon hearing this, Ash and the others decide to head to the Fuego Ironworks to save them.

Cyrus has succeeded in his goal of awakening Dialga and Palkia and now the entire Sinnoh region is in danger. Cyrus plans to rebuild the world in his image, but that means the destruction of everything. Can Ash, Dawn, Brock, Looker, and Cynthia stop Team Galactic and save Sinnoh?