As they reach the other end of Big Island, Ash & Co. rest at the Pokémon Center, however when Ash wakes up he finds that Cilan, Iris and Axew's face has been replaced with that of a Beheeyem. Rushing outside, he finds that everyone in town, both people and Pokémon, have had their face turned into a Beheeyem face. Ash worries with what to do until he bumps into two people who have yet to be converted, Jessie and James. It turns out they are looking for Meowth who has disappeared. Ash decides to enlist the help of his enemies in order to try and restore the town. Will they succeed?

Ash, Pikachu, and friends must stop Mewtwo and a group of Genesect from the destroying the city.