As they travel towards Cyllage City, Team Rocket encounter a new adversary in Madame X and her partner Pokémon, Malamar. Madame X had managed to use her powers to brainwash Jessie and James into doing her bidding before Meowth managed to escape. However, without any allies in this region, Meowth must turn to Ash & Co. for help. However, one by one, everyone starts to get brainwashed, including Pikachu. What will Ash do? Will he and Meowth manage to stop Madame X?

Heading towards Cyllage City, Ash & Co. meet up with the Santalune City Gym Leader, Viola who informs them about the Battle Chateau, where people go for some of the strongest Pokémon battles. While there, they meet the Gym Leader of the next city, Grant. Due to the amount of wins both Grant & Viola have at the Chateau, it is their time to battle eachother. Who will win? Will Ash manage to win his battles in the Chateau?