After failing to capture Pikachu, Jessie, James, and Meowth go their separate ways. Butch and Cassidy also split which leads to Jessie teaming up with Butch and James with Cassidy. Both teams then try to prove who is better by capturing Pikachu and Pokémon that trainers are using in a fake battle tournament set up by them.

Finally at the final Battle Frontier Facility, the Battle Pyramid, Ash & Co. find a challenge just to find Brandon, the Frontier Brain. Once found, while they are going through the Pyramid, Ash gets adversely affected by one of the artifacts inside. Will Ash snap out of it in order to battle Brandon and the legendary Pokémon Regirock?