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While Andrew and Nick deal with parental crises, Jessi meets her new sibling, and Matthew realizes he's made Jay into a different person.
Elijah tries to figure out why he doesen't have the same urges as his friends. A jealous Andrew hops a train to Vermont to surprise Bernie.
A sudden outbreak of body-swapping yields awkward situations and poignant revelations galore.
Season six focuses on the theme of family as the beloved characters continue each of their journeys, discovering that while you can't always pick your family, you can surround yourself with those that love you for who you are.